Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia

Purpose: A promotional animation for the recent publication in Nature Cancer from the Simpson Querrey Institute for Epigenetics that describes the effects of ASXL1 mutations in BAP1 and the role it plays in leukemic pathogenesis. As well as the discovery of an inhibitor that could help. Paper: https://www.nature.com/articles/s43018-021-00199-4

Audience: General audience and Professionals in the field.

Date: 2021

Software: Autodesk 3dsMax, Vray, VMD, Pixologic Zbrush, PDB, Adobe Photoshop, Adobe Illustrator, and Adobe After Effects